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Hydroxyapatite vs Fluoride: What’s the Difference and How Do You Choose? By Kate · Reviewed by Allen· Updated October 26, 2026Hydroxyapatite and fluoride are both used in toothpaste to support stronger teeth, but they work in different ways. Fluoride helps enamel resist acid and supports remineralization. Hydroxyapatite is the calcium phosphate mineral that makes up…